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KMID : 0381119790010010010
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Genes and Genomics
1979 Volume.1 No. 1 p.10 ~ p.17
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REPLICATION PATTERN AND LOCATION OF CHROMOSOME BREAKAGE IN HUMAN LYMPHOCYTES
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KIM MY.-A.
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Abstract
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The relationship between DNA replication patterns and chromosome breaks is studied by BUdR labelling.
Chromosome breaks can be induced specifically in the S-phase by incorporation of BUdR. The distributions of predilections sites of chromosome breakages both by X-ray induced and translocation cases are shown. Break points are distributed 1:2 by translocation and 3:5 by X-ray induced cases between G-and R-bands. The frequency of break points by X-ray inductions is highly correlated to the relative length of chromosomes (r = 0.84) however relatively less correlated patte군 are shown by translocation cases (r = 0.51).
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KEYWORD
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